P129 CHONDROCYTES IN OSTEOARTHRITIS DE-DIFFERENTIATE BEFORE RE-DIFFERENTIATING TO A ‘DEGRADATIVE’ PHENOTYPE

Degradative enzymes in osteoarthritis.

A central feature of the osteoarthritic disease process involves erosive destruction of the articular cartilage extracellular matrix (ECM) on the surfaces of diarthrotic joints. The resultant loss of joint function makes studies on mechanisms underlying ECM degradation critical for treatment of the disease and prevention of disability. Candidate pathways to account for the loss of cartilage inv...

Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis

Inflammatory chemo- and cytokines and matrix-degrading proteases underlie the progression of osteoarthritis (OA). Aiming to define upstream regulators for these disease markers, we pursued initial evidence for an upregulation of members of the adhesion/growth-regulatory galectin family. Immunohistochemical localization of galectin-3 (Gal-3) in sections of human cartilage with increasing levels ...

De re and De dicto Modality in Islamic Traditional Logic

Can the kidney volume help to differentiate the types of rejection before biopsy?

Background: The aim of this study was to use the volume of the graft as an adjunct tool for better decision making. Methods: Kidney transplanted patients with acute azotemia and documented volume and finally a biopsy were enrolled in this study‌. Graft volumes between rejected patients (antibody-mediated rejection {AMR} and cell - mediated rejection {CMR}) and ‌non rejected but azotemic patien...

ASIM May p129-134

129 A n accurate diagnosis built on history, physical examination, and testing is the critical first step in successful management of epilepsy and isolated seizures in children. Determining the risk for recurrence is, of course, the paramount concern to both clinician and parents. In the United States, the estimates of recurrence risk range from 23% to 71%, with most of the variation in estimat...